Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles?

摘要

The aim of the study was to assess chosen factors of geneticsusceptibility to DMT1: DRB1, DQB1, and TNF-αpolymorphisms-308 (G/A) in children with DMT1 and their up-to-nowhealthy siblings. Then we tested whether the association betweenTNF-α genes and DMT1 is independent of HLA. 87 diabeticchildren, their 78 siblings, and 85 persons from healthy controlgroup were followed up. The highest risk of DMT1 was connectedwith alleles: DRB1*0401 (OR = 3.39; CI: 1.55–7.41),DRB1*0301 (OR = 2.72; CI: 1.48–5.01), DQB1*0201 (OR =4.04; CI: 2.17–7.52), DQB1*0302 (OR = 5.08; CI:2.54–10.14), and TNF-α-308 A allele (OR = 2.59; CI:1.23–5.44). Moreover linkage disequilibrium for TNF-α-308A allele with DRB1*0301 and DQB1*0201 was observed inboth diabetic children and their siblings. Diabetic children andtheir siblings present similar genetic risk factors for DMT1. Theassociation between TNF-α-308 A allele and DMT1 isdependent of HLA-DRB1 and DQB1 alleles.